The CF gene: 10 years on

Gene therapy for CF.

Background: Transcription factors regulate gene expression by interacting with their specific DNA binding sites. Some transcription factors, particularly those involved in transcription initiation, always bind close to transcription start sites (TSS). Others have no such preference and are functional on sites even tens of thousands of base pairs (bp) away from the TSS. The Cyclic-AMP response e...

Diagnosing CF: sweat, blood and years.

evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273:408–12. 30 Allen MS, Darling GE, Pechet TTV, et al. Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of the randomized, prospective ACOSOG Z0030 trial. Ann Thorac Surg 2006;81:1013–20. 31 Mohan A,...

Informatics 10 Years Back , 10 Years Ahead

Interpretation is a theory of approximation of the be— havior of dynamic discrete systems such as the formal seman­ tics ofprograms. Since such behaviors can be characterized by fixpoints, the theory essentially provides constructive and ef— fective methods for fixpoint approximation and checking by abstraction. Non—conventionalapplications of abstract interpretation in— clude the design of hie...

Microprocessors - 10 Years Back, 10 Years Ahead

Critical Care – 10 years on

When Critical Care's first issue was published we were on the brink of the electronic revolution. In the same year the number of online websites reached 1 million (a mere fraction of the vast resources now available) and for the first time more e-mails were sent than letters [1]. The Internet was swiftly seeping into mainstream use. The initial concept behind Critical Care was to make the most ...